ZNF451

Zinc finger protein 451 is a novel nuclear protein that in humans is encoded by the ZNF451 gene.[5][6]

ZNF451
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5D2M
Identifiers
Aliases	ZNF451, COASTER, dJ417I1.1, zinc finger protein 451
External IDs	OMIM: 615708 MGI: 2137896 HomoloGene: 9188 GeneCards: ZNF451
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.1 Start 57,086,844 bp[1] End 57,170,305 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 B|1 12.81 cM Start 33,761,545 bp[2] End 33,814,595 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SUMO ligase activity • GO:0001106 transcription corepressor activity • GO:0001948 protein binding • metal ion binding • nucleic acid binding • transferase activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II core promoter sequence-specific DNA binding Cellular component • PML body • cell nucleus • nucleoplasm • histone methyltransferase complex Biological process • negative regulation of transcription initiation from RNA polymerase II promoter • negative regulation of histone H3-K9 acetylation • regulation of transcription, DNA-templated • negative regulation of transforming growth factor beta receptor signaling pathway • protein sumoylation • transcription, DNA-templated • regulation of gene expression Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26036	98403
Ensembl	ENSG00000112200	ENSMUSG00000042197
UniProt	Q9Y4E5	Q8C0P7
RefSeq (mRNA)	NM_001031623 NM_001257273 NM_015555	NM_001290699 NM_001290700 NM_133817 NM_001359274 NM_001359275
RefSeq (protein)	NP_001026794 NP_001244202 NP_056370	NP_001277628 NP_001277629 NP_598578 NP_001346203 NP_001346204
Location (UCSC)	Chr 6: 57.09 – 57.17 Mb	Chr 1: 33.76 – 33.81 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000112200 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042197 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
6. "Entrez Gene: ZNF451 zinc finger protein 451".

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• ZNF451+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.