TLX1

T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11.[5][6][7][8][9]

TLX1
Identifiers
Aliases	TLX1, HOX11, TCL3, T-cell leukemia homeobox 1, T cell leukemia homeobox 1
External IDs	OMIM: 186770 MGI: 98769 HomoloGene: 4031 GeneCards: TLX1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.31 Start 101,131,300 bp[1] End 101,137,789 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 38.45 cM Start 45,150,680 bp[2] End 45,156,943 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity Cellular component • cell nucleus Biological process • multicellular organism development • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3195	21908
Ensembl	ENSG00000107807	ENSMUSG00000025215
UniProt	P31314	P43345
RefSeq (mRNA)	NM_001195517 NM_005521	NM_021901
RefSeq (protein)	NP_001182446 NP_005512	n/a
Location (UCSC)	Chr 10: 101.13 – 101.14 Mb	Chr 19: 45.15 – 45.16 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TLX1 has been shown to interact with PPP1CC,[10] PPP2CB[10] and PPP2CA.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000107807 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025215 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ (Jul 1991). "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia". Science. 253 (5015): 79–82. doi:10.1126/science.1676542. PMID 1676542.
6. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
7. "Entrez Gene: TLX1 T-cell leukemia homeobox 1".
8. Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 8900–4. doi:10.1073/pnas.88.20.8900. PMC 52618. PMID 1681546.
9. Dubé ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC, Crist WM, Carroll AJ, Minowada J (Dec 1991). "A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)". Blood. 78 (11): 2996–3003. doi:10.1182/blood.V78.11.2996.2996. PMID 1683261.
10. Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195. S2CID 608633.

Further reading

• Allen TD, Zhu YX, Hawley TS, Hawley RG (Oct 2000). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leukemia & Lymphoma. 39 (3–4): 241–56. doi:10.3109/10428190009065824. PMID 11342305. S2CID 27407074.
• Lu M, Zhang N, Ho AD (Jul 1992). "Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells". Oncogene. 7 (7): 1325–30. PMID 1352396.
• Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 8900–4. doi:10.1073/pnas.88.20.8900. PMC 52618. PMID 1681546.
• Lu M, Gong ZY, Shen WF, Ho AD (Oct 1991). "The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein". The EMBO Journal. 10 (10): 2905–10. doi:10.1002/j.1460-2075.1991.tb07840.x. PMC 453003. PMID 1717256.
• Dear TN, Colledge WH, Carlton MB, Lavenir I, Larson T, Smith AJ, Warren AJ, Evans MJ, Sofroniew MV, Rabbitts TH (Sep 1995). "The Hox11 gene is essential for cell survival during spleen development". Development. 121 (9): 2909–15. PMID 7555717.
• Dear TN, Sanchez-Garcia I, Rabbitts TH (May 1993). "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes". Proceedings of the National Academy of Sciences of the United States of America. 90 (10): 4431–5. doi:10.1073/pnas.90.10.4431. PMC 46525. PMID 8099440.
• Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195. S2CID 608633.
• Brake RL, Kees UR, Watt PM (Oct 1998). "Multiple negative elements contribute to repression of the HOX11 proto-oncogene". Oncogene. 17 (14): 1787–95. doi:10.1038/sj.onc.1202078. PMID 9778044.
• Zhang N, Shen W, Hawley RG, Lu M (Apr 1999). "HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization". Oncogene. 18 (13): 2273–9. doi:10.1038/sj.onc.1202545. PMID 10327073.
• Watt PM, Ranford PR, Kees UR (Jun 1999). "Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line". Gene. 234 (1): 169–76. doi:10.1016/S0378-1119(99)00157-2. PMID 10393251.
• Brake RL, Kees UR, Watt PM (May 2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11". Biochemical and Biophysical Research Communications. 294 (1): 23–34. doi:10.1016/S0006-291X(02)00426-6. PMID 12054735.
• Bodenmiller DM, Baxter CS, Hansen DV, Potter SS (Apr 2002). "Phylogenetic analysis of Hoxa 11 sequences reveals absence of transposable elements, conservation of transcription factor binding sites, and suggests antisense coding function". DNA Sequence. 13 (2): 77–83. doi:10.1080/10425170290029981. PMID 12180349. S2CID 38713800.
• Cavé H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A, Malet M, Boutard P, Benoit Y, Mauvieux L, Lutz P, Méchinaud F, Grardel N, Mazingue F, Dupont M, Margueritte G, Pages MP, Bertrand Y, Plouvier E, Brunie G, Bastard C, Plantaz D, Vande Velde I, Hagemeijer A, Speleman F, Lessard M, Otten J, Vilmer E, Dastugue N (Jan 2004). "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951". Blood. 103 (2): 442–50. doi:10.1182/blood-2003-05-1495. PMID 14504110.
• Hoffmann K, Dixon DN, Greene WK, Ford J, Taplin R, Kees UR (Dec 2004). "A microarray model system identifies potential new target genes of the proto-oncogene HOX11". Genes, Chromosomes & Cancer. 41 (4): 309–20. doi:10.1002/gcc.20104. PMID 15384172. S2CID 19475690.
• Riz I, Hawley RG (Aug 2005). "G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia". Oncogene. 24 (36): 5561–75. doi:10.1038/sj.onc.1208727. PMC 2408753. PMID 15897879.
• Heidari M, Rice KL, Phillips JK, Kees UR, Greene WK (Feb 2006). "The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells". Leukemia. 20 (2): 304–12. doi:10.1038/sj.leu.2404071. PMID 16357834.
• Chen E, Lim MS, Rosic-Kablar S, Liu J, Jolicoeur P, Dubé ID, Hough MR (Apr 2006). "Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice". Oncogene. 25 (18): 2575–87. doi:10.1038/sj.onc.1209285. PMID 16407851.