HOXA4

Homeobox A4, also known as HOXA4, is a protein which in humans is encoded by the HOXA4 gene.[5][6]

HOXA4
Identifiers
AliasesHOXA4, HOX1, HOX1D, homeobox A4
External IDsOMIM: 142953 MGI: 96176 HomoloGene: 37583 GeneCards: HOXA4
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7p15.2Start27,128,507 bp[1]
End27,130,780 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3201

15401

Ensembl

ENSG00000197576

ENSMUSG00000000942

UniProt

Q00056

P06798

RefSeq (mRNA)

NM_002141

NM_008265

RefSeq (protein)

NP_002132

NP_032291

Location (UCSC)Chr 7: 27.13 – 27.13 MbChr 6: 52.19 – 52.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes.[7] Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.[5]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000197576 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000000942 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: HOXA4 homeobox A4".
  6. McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  7. Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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