ELF2

E74-like factor 2 (ELF2), formerly known as new Ets-related factor (NERF), is an ETS family transcription factor.[5] In humans this protein is encoded by the ELF2 gene.[6]

ELF2
Identifiers
Aliases	ELF2, EU32, NERF, NERF-1A, NERF-1B, NERF-1a,b, NERF-2, E74 like ETS transcription factor 2
External IDs	MGI: 1916507 HomoloGene: 5006 GeneCards: ELF2
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.1 Start 139,028,112 bp[1] End 139,177,218 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 C Start 51,252,720 bp[2] End 51,340,663 bp[2]
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • DNA binding • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • cytosol • nuclear body • nucleoplasm Biological process • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-templated • cell differentiation • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of B cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1998	69257
Ensembl	ENSG00000109381	ENSMUSG00000037174
UniProt	Q15723	Q9JHC9
RefSeq (mRNA)	NM_001276457 NM_001276458 NM_001276459 NM_006874 NM_201999 NM_001331036	NM_001291059 NM_001291062 NM_001291063 NM_023502 NM_001356358
RefSeq (protein)	NP_001263386 NP_001263387 NP_001263388 NP_001317965 NP_006865 NP_973728 NP_001358253 NP_001358265 NP_001358266 NP_001358267 NP_001358268	NP_001277988 NP_001277991 NP_001277992 NP_075991 NP_001343287
Location (UCSC)	Chr 4: 139.03 – 139.18 Mb	Chr 3: 51.25 – 51.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000109381 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037174 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA (September 1996). "Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1". Mol. Cell. Biol. 16 (9): 5091–106. doi:10.1128/MCB.16.9.5091. PMC 231510. PMID 8756667.
6. "Entrez Gene: ELF2 E74-like factor 2 (ets domain transcription factor)".

Further reading

• Wilkinson DA, Neale GA, Mao S, et al. (1997). "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia". Leukemia. 11 (1): 86–96. doi:10.1038/sj.leu.2400516. PMID 9001422.
• Mao S, Frank RC, Zhang J, et al. (1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Mol. Cell. Biol. 19 (5): 3635–44. doi:10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087.
• Christensen RA, Fujikawa K, Madore R, et al. (2002). "NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia". J. Cell. Biochem. 85 (3): 505–15. doi:10.1002/jcb.10148. PMID 11967990. S2CID 36902890.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". J. Biol. Chem. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang B, Tomita Y, Qiu Y, et al. (2007). "E74-like factor 2 regulates valosin-containing protein expression". Biochem. Biophys. Res. Commun. 356 (3): 536–41. doi:10.1016/j.bbrc.2007.02.160. PMID 17368566.