KLF8

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene.[5] KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.[6]

KLF8
Identifiers
Aliases	KLF8, BKLF3, ZNF741, Kruppel-like factor 8, Kruppel like factor 8
External IDs	OMIM: 300286 MGI: 2442430 HomoloGene: 68549 GeneCards: KLF8
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.21 Start 56,232,356 bp[1] End 56,291,531 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F3 Start 153,237,466 bp[2] End 153,396,132 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • metal ion binding • nucleic acid binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleoplasm • cytosol • aggresome Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11279	245671
Ensembl	ENSG00000102349	ENSMUSG00000041649
UniProt	O95600	Q8BLM0
RefSeq (mRNA)	NM_001159296 NM_007250 NM_001324099 NM_001324100 NM_001324102 NM_001324104 NM_001324105	NM_173780 NM_001357183
RefSeq (protein)	NP_001152768 NP_001311028 NP_001311029 NP_001311031 NP_001311033 NP_001311034 NP_009181	NP_776141 NP_001344112
Location (UCSC)	Chr X: 56.23 – 56.29 Mb	Chr X: 153.24 – 153.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

KLF8 has been shown to interact with CTBP2.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000102349 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041649 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: KLF8 Kruppel-like factor 8".
6. Alister P. W. Funnell; et al. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". asm.org. Retrieved 12 January 2019.
7. van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.

Further reading

• van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.
• Lossi AM, Laugier-Anfossi F, Depetris D, Gecz J, Gedeon A, Kooy F, Schwartz C, Mattei MG, Croquette MF, Villard L (Feb 2002). "Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation". Journal of Medical Genetics. 39 (2): 113–7. doi:10.1136/jmg.39.2.113. PMC 1735036. PMID 11836360.
• Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (Apr 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". The Journal of Biological Chemistry. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.
• Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL (Jun 2003). "Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression". Molecular Cell. 11 (6): 1503–15. doi:10.1016/S1097-2765(03)00179-5. PMID 12820964.
• Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element". Blood Cells, Molecules & Diseases. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.
• Wang X, Zhao J (Jan 2007). "KLF8 transcription factor participates in oncogenic transformation". Oncogene. 26 (3): 456–61. doi:10.1038/sj.onc.1209796. PMID 16832343.
• Hu JH, Navas P, Cao H, Stamatoyannopoulos G, Song CZ (Mar 2007). "Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation". Journal of Molecular Biology. 366 (4): 1064–73. doi:10.1016/j.jmb.2006.12.047. PMC 1907364. PMID 17224162.
• Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, Zhao J (Aug 2007). "Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion". Cancer Research. 67 (15): 7184–93. doi:10.1158/0008-5472.CAN-06-4729. PMID 17671186.

External links

• KLF8 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)