LYL1

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.[5][6]

LYL1
Identifiers
Aliases	LYL1, bHLHa18, lymphoblastic leukemia associated hematopoiesis regulator 1, basic helix-loop-helix family member, LYL1 basic helix-loop-helix family member
External IDs	OMIM: 151440 MGI: 96891 HomoloGene: 4078 GeneCards: LYL1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 13,099,033 bp[1] End 13,103,161 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C2|8 41.02 cM Start 84,701,449 bp[2] End 84,704,940 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001948 protein binding • protein dimerization activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • positive regulation of transcription, DNA-templated • B cell differentiation • definitive hemopoiesis • regulation of transcription, DNA-templated • transcription, DNA-templated • blood vessel maturation • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4066	17095
Ensembl	ENSG00000104903	ENSMUSG00000034041
UniProt	P12980	P27792
RefSeq (mRNA)	NM_005583	NM_008535
RefSeq (protein)	NP_005574	NP_032561
Location (UCSC)	Chr 19: 13.1 – 13.1 Mb	Chr 8: 84.7 – 84.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

LYL1 has been shown to interact with TCF3[7] and NFKB1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000104903 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034041 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mellentin JD, Smith SD, Cleary ML (July 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell. 58 (1): 77–83. doi:10.1016/0092-8674(89)90404-2. PMID 2752424. S2CID 24737263.
6. "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1".
7. Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Molecular and Cellular Biology. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC 231228. PMID 8628307.
8. Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.

Further reading

• Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proceedings of the National Academy of Sciences of the United States of America. 88 (24): 11416–20. Bibcode:1991PNAS...8811416X. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
• Kuo SS, Mellentin JD, Copeland NG, Gilbert DJ, Jenkins NA, Cleary ML (June 1991). "Structure, chromosome mapping, and expression of the mouse Lyl-1 gene". Oncogene. 6 (6): 961–8. PMID 2067848.
• Saltman DL, Mellentin JD, Smith SD, Cleary ML (November 1990). "Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization". Genes, Chromosomes & Cancer. 2 (4): 259–65. doi:10.1002/gcc.2870020402. PMID 2268576. S2CID 103922.
• Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". The EMBO Journal. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
• Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A (January 1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.
• Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Molecular and Cellular Biology. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC 231228. PMID 8628307.
• Mahajan MA, Park ST, Sun XH (June 1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins". Oncogene. 12 (11): 2343–50. PMID 8649774.
• Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.
• Meng YS, Khoury H, Dick JE, Minden MD (November 2005). "Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia". Leukemia. 19 (11): 1941–7. doi:10.1038/sj.leu.2403836. PMID 16094422.

External links

• LYL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)