MXD3

MAX dimerization protein 3 is a protein that in humans is encoded by the MXD3 gene located on Chromosome 5.[5][6]

MXD3
Identifiers
Aliases	MXD3, BHLHC13, MAD3, MYX, MAX dimerization protein 3
External IDs	OMIM: 609450 MGI: 104987 HomoloGene: 32333 GeneCards: MXD3
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 177,301,461 bp[1] End 177,312,757 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B1|13 29.8 cM Start 55,325,168 bp[2] End 55,329,823 bp[2]
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • protein dimerization activity • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • RNA polymerase II transcription factor complex Biological process • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83463	17121
Ensembl	ENSG00000213347	ENSMUSG00000021485
UniProt	Q9BW11	Q80US8
RefSeq (mRNA)	NM_031300 NM_001142935	NM_016662
RefSeq (protein)	NP_001136407 NP_112590 NP_112590.1	NP_057871
Location (UCSC)	Chr 5: 177.3 – 177.31 Mb	Chr 13: 55.33 – 55.33 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

MXD3 is a basic helix-loop-helix protein belonging to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex.[6] MXD3 is a transcriptional repressor that is specifically expressed during S phase of the cell cycle.[7] The protein is implicated in both normal neural development and in the development of brain cancer. In medulloblastoma cells, MXD3 binds E-box sequences, leading to increased cell proliferation at moderate MXD3 levels but increased cell death and apoptosis at higher expression levels.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000213347 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021485 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". EMBO J. 14 (22): 5646–59. doi:10.1002/j.1460-2075.1995.tb00252.x. PMC 394680. PMID 8521822.
6. "Entrez Gene: MXD3 MAX dimerization protein 3".
7. Fox EJ, Wright SC (February 2003). "The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1". Biochem J. 370 (1): 307–13. doi:10.1042/bj20021583. PMC 1223166. PMID 12444919.
8. Barisone GA, Ngo T, Tran M, Cortes D, Shahi MH, Nguyen TV, Perez-Lanza D, Matayasuwan W, Díaz E (July 2012). "Role of MXD3 in proliferation of DAOY human medulloblastoma cells". PLOS ONE. 7 (7): e38508. Bibcode:2012PLoSO...738508B. doi:10.1371/journal.pone.0038508. PMC 3393725. PMID 22808009.