ZNF274

Zinc finger protein 274 is a protein that in humans is encoded by the ZNF274 gene.[5][6]

ZNF274
Identifiers
Aliases	ZNF274, HFB101, ZF2, ZKSCAN19, ZSCAN51, zinc finger protein 274
External IDs	OMIM: 605467 MGI: 2176229 HomoloGene: 129707 GeneCards: ZNF274
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.43 Start 58,183,029 bp[1] End 58,213,562 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B3 Start 65,278,814 bp[2] End 65,304,221 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • DNA binding • GO:0001948 protein binding • GO:0001106 transcription corepressor activity • metal ion binding • nucleic acid binding • chromatin binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • nucleolus • intracellular • cell nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of histone H3-K9 trimethylation • negative regulation of nucleic acid-templated transcription • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10782	170936
Ensembl	ENSG00000171606	ENSMUSG00000021514
UniProt	Q96GC6	Q921B4
RefSeq (mRNA)	NM_001278734 NM_001278735 NM_016324 NM_016325 NM_133502	NM_178364
RefSeq (protein)	NP_001265663 NP_057408 NP_057409 NP_598009	n/a
Location (UCSC)	Chr 19: 58.18 – 58.21 Mb	Chr 13: 65.28 – 65.3 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000171606 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021514 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yano K, Ueki N, Oda T, Seki N, Masuho Y, Muramatsu M (Jun 2000). "Identification and characterization of human ZNF274 cDNA, which encodes a novel kruppel-type zinc-finger protein having nucleolar targeting ability". Genomics. 65 (1): 75–80. doi:10.1006/geno.2000.6140. PMID 10777669.
6. "Entrez Gene: ZNF274 zinc finger protein 274".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Petroni D, Bartolini E, Chiaramonte R, et al. (1999). "Computer sequence analysis of human highly conserved zinc finger modules". DNA Seq. 9 (3): 163–9. doi:10.3109/10425179809072191. PMID 10520746.
• Casademunt E, Carter BD, Benzel I, et al. (2000). "The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death". EMBO J. 18 (21): 6050–61. doi:10.1093/emboj/18.21.6050. PMC 1171670. PMID 10545116.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Sripathy SP, Stevens J, Schultz DC (2007). "The KAP1 Corepressor Functions To Coordinate the Assembly of De Novo HP1-Demarcated Microenvironments of Heterochromatin Required for KRAB Zinc Finger Protein-Mediated Transcriptional Repression". Mol. Cell. Biol. 26 (22): 8623–38. doi:10.1128/MCB.00487-06. PMC 1636786. PMID 16954381.

External links

• ZNF274+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook ZNF274

This article incorporates text from the United States National Library of Medicine, which is in the public domain.