OR10G4

Olfactory receptor 10G4 is a protein that in humans is encoded by the OR10G4 gene.[4]

OR10G4
Identifiers
Aliases	OR10G4, OR11-278, olfactory receptor family 10 subfamily G member 4
External IDs	MGI: 3030814 HomoloGene: 81557 GeneCards: OR10G4
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.2 Start 124,012,997 bp[1] End 124,018,732 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • olfactory receptor activity Cellular component • cell membrane • membrane • integral component of membrane Biological process • signal transduction • response to stimulus • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	390264	259110
Ensembl	ENSG00000254737	ENSMUSG00000060254
UniProt	Q8NGN3	Q8VH08
RefSeq (mRNA)	NM_001004462	NM_147106
RefSeq (protein)	NP_001004462	NP_667317
Location (UCSC)	Chr 11: 124.01 – 124.02 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]

Genetic differences

Nonsynonymous substitutions in the OR10G4 gene have a significant effect on the perception of the "smoky" odorant guaiacol. Individuals with mutations that reduce the affinity of the OR10G4 receptor for guaiacol have a reduced sensitivity to it, and the same people who report guaiacol as weaker tend to rate it as more pleasant.[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000254737 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: OR10G4 olfactory receptor, family 10, subfamily G, member 4".
5. Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC 3990440. PMID 24316890.

Further reading

• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR10G4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.