OR1A2

Olfactory receptor 1A2 is a protein that in humans is encoded by the OR1A2 gene.[3][4]

OR1A2
Identifiers
AliasesOR1A2, OR17-6, olfactory receptor family 1 subfamily A member 2
External IDsOMIM: 618047 GeneCards: OR1A2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.3Start3,197,519 bp[1]
End3,198,448 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

26189

n/a

Ensembl

ENSG00000172150

n/a

UniProt

Q9Y585

n/a

RefSeq (mRNA)

NM_012352

n/a

RefSeq (protein)

NP_036484

n/a

Location (UCSC)Chr 17: 3.2 – 3.2 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]

Ligands

The known ligands of OR1A2 are near-identical to those of OR1A1.[5] Examples of known ligands, most of which have citrus or fruity smells:[5][6]

See also

Notes
  1. GRCh38: Ensembl release 89: ENSG00000172150 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D (Apr 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334. S2CID 23416814.
  4. "Entrez Gene: OR1A2 olfactory receptor, family 1, subfamily A, member 2".
  5. Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID 17601748.
  6. Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.

References

Further reading
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