OR51B4

Olfactory receptor 51B4 is a protein that in humans is encoded by the OR51B4 gene.[5]

OR51B4
Identifiers
Aliases	OR51B4, HOR5'Beta1, olfactory receptor family 51 subfamily B member 4
External IDs	MGI: 1341906 HomoloGene: 88376 GeneCards: OR51B4
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 5,301,014 bp[1] End 5,301,946 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 103,879,443 bp[2] End 103,886,252 bp[2]
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • membrane Biological process • sensory perception of smell • signal transduction • response to stimulus • detection of chemical stimulus involved in sensory perception of smell • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79339	18367
Ensembl	ENSG00000183251	ENSMUSG00000058200
UniProt	Q9Y5P0	F8VQ01
RefSeq (mRNA)	NM_033179	NM_013618
RefSeq (protein)	NP_149419	NP_038646
Location (UCSC)	Chr 11: 5.3 – 5.3 Mb	Chr 7: 103.88 – 103.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000183251 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058200 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR51B4 olfactory receptor, family 51, subfamily B, member 4".

Further reading

• Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M, von Doorninck JH (April 1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 5129–34. doi:10.1073/pnas.96.9.5129. PMC 21828. PMID 10220430.
• Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R (December 2000). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proceedings of the National Academy of Sciences of the United States of America. 97 (26): 14560–5. doi:10.1073/pnas.97.26.14560. PMC 18958. PMID 11121057.

External links

• OR51B4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.