OR2A12

Olfactory receptor 2A12 is a protein that in humans is encoded by the OR2A12 gene.[4]

OR2A12
Identifiers
Aliases	OR2A12, OR2A12P, OR2A16P, olfactory receptor family 2 subfamily A member 12
External IDs	MGI: 3030280 HomoloGene: 17179 GeneCards: OR2A12
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q35 Start 144,086,278 bp[1] End 144,098,953 bp[1]
Gene ontology Molecular function • signal transducer activity • olfactory receptor activity • G-protein coupled receptor activity Cellular component • cell membrane • membrane • integral component of membrane Biological process • sensory perception of smell • signal transduction • response to stimulus • detection of chemical stimulus involved in sensory perception of smell • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	346525	258292
Ensembl	ENSG00000221858 ENSG00000284949	ENSMUSG00000073111
UniProt	Q8NGT7	Q8VEV0
RefSeq (mRNA)	NM_001004135	NM_146295
RefSeq (protein)	NP_001004135	NP_666407
Location (UCSC)	Chr 7: 144.09 – 144.1 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]

See also

• Olfactory receptor

References

1. ENSG00000284949 GRCh38: Ensembl release 89: ENSG00000221858, ENSG00000284949 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: OR2A12 olfactory receptor, family 2, subfamily A, member 12".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.145.6233. doi:10.1006/geno.2002.6830. PMID 12213199.
• Gilad Y, Lancet D (2003). "Population differences in the human functional olfactory repertoire". Mol. Biol. Evol. 20 (3): 307–14. doi:10.1093/molbev/msg013. PMID 12644552.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR2A12+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.