OR51E2

Olfactory receptor 51E2 is a protein that in humans is encoded by the OR51E2 gene.[5][6]

OR51E2
Identifiers
Aliases	OR51E2, OR51E3P, OR52A2, PSGR, olfactory receptor family 51 subfamily E member 2, HPRAJ
External IDs	OMIM: 611268 MGI: 2157548 HomoloGene: 23713 GeneCards: OR51E2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 4,680,171 bp[1] End 4,697,854 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 102,738,511 bp[2] End 102,759,471 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • olfactory receptor activity • G-protein coupled receptor activity • steroid hormone receptor activity • signaling receptor activity Cellular component • membrane • integral component of membrane • cell membrane • early endosome membrane • intracellular organelle • endosome Biological process • sensory perception of smell • steroid hormone mediated signaling pathway • signal transduction • response to stimulus • detection of chemical stimulus involved in sensory perception of smell • positive regulation of blood pressure • cellular response to fatty acid • positive regulation of renin secretion into blood stream • G-protein coupled receptor signaling pathway • cell migration • melanocyte differentiation • positive regulation of cAMP-mediated signaling • melanocyte proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81285	170639
Ensembl	ENSG00000167332	ENSMUSG00000043366
UniProt	Q9H255	Q8VBV9
RefSeq (mRNA)	NM_030774	NM_001168503 NM_130866
RefSeq (protein)	NP_110401	NP_001161975 NP_570936
Location (UCSC)	Chr 11: 4.68 – 4.7 Mb	Chr 7: 102.74 – 102.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

Ligands

OR51E2 is a relatively narrowly tuned olfactory receptor, meaning it responds only to a relatively small set of related odorants.[7]

OR51E2 responds to short-chain fatty acids,[8] including in particular propionic acid.[7]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000167332 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043366 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, Zou Z, Srikantan V, Augustus M, Roschke V, Carter K, McLeod DG, Moul JW, Soppett D, Srivastava S (Dec 2000). "PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer". Cancer Res. 60 (23): 6568–72. PMID 11118034.
6. "Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2".
7. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.
8. Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, Brunet I, Wan LX, Rey F, Wang T, Firestein SJ, Yanagisawa M, Gordon JI, Eichmann A, Peti-Peterdi J, Caplan MJ (March 2013). "Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation". Proceedings of the National Academy of Sciences of the United States of America. 110 (11): 4410–5. doi:10.1073/pnas.1215927110. PMC 3600440. PMID 23401498.

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Xia C, Ma W, Wang F, et al. (2001). "Identification of a prostate-specific G-protein coupled receptor in prostate cancer". Oncogene. 20 (41): 5903–7. doi:10.1038/sj.onc.1204803. PMID 11593396.
• Yuan TT, Toy P, McClary JA, et al. (2002). "Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species". Gene. 278 (1–2): 41–51. doi:10.1016/S0378-1119(01)00709-0. PMID 11707321.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Weng J, Wang J, Cai Y, et al. (2005). "Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers". Int. J. Cancer. 113 (5): 811–8. doi:10.1002/ijc.20635. PMID 15499628. S2CID 27473061.
• Weng J, Ma W, Mitchell D, et al. (2006). "Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors". J. Cell. Biochem. 96 (5): 1034–48. doi:10.1002/jcb.20600. PMID 16149059. S2CID 20908653.
• Xu LL, Sun C, Petrovics G, et al. (2006). "Quantitative expression profile of PSGR in prostate cancer". Prostate Cancer Prostatic Dis. 9 (1): 56–61. doi:10.1038/sj.pcan.4500836. PMID 16231015.
• Wang J, Weng J, Cai Y, et al. (2006). "The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase". Prostate. 66 (8): 847–57. doi:10.1002/pros.20389. PMID 16491480. S2CID 25548828.

External links

• OR51E2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.