OR2C1

Olfactory receptor 2C1 is a protein that in humans is encoded by the OR2C1 gene.[5][6]

OR2C1
Identifiers
Aliases	OR2C1, OLFmf3, OR2C2P, olfactory receptor family 2 subfamily C member 1
External IDs	MGI: 106182 HomoloGene: 7459 GeneCards: OR2C1
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 3,355,889 bp[1] End 3,357,306 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A1 Start 3,830,878 bp[2] End 3,844,747 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • olfactory receptor activity • odorant binding Cellular component • integral component of membrane • cell membrane • membrane • cell cortex Biological process • signal transduction • response to stimulus • detection of chemical stimulus involved in sensory perception of smell • sensory perception of smell • G-protein coupled receptor signaling pathway • detection of chemical stimulus involved in sensory perception Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4993	18312
Ensembl	ENSG00000168158	ENSMUSG00000059043
UniProt	O95371	P23275
RefSeq (mRNA)	NM_012368	NM_008762
RefSeq (protein)	NP_036500	NP_032788
Location (UCSC)	Chr 16: 3.36 – 3.36 Mb	Chr 16: 3.83 – 3.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

Ligands

• Octanethiol[7]
• Nonanethiol[7]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000168158 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059043 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Centola M, Chen X, Sood R, Deng Z, Aksentijevich I, Blake T, Ricke DO, Chen X, Wood G, Zaks N, Richards N, Krizman D, Mansfield E, Apostolou S, Liu J, Shafran N, Vedula A, Hamon M, Cercek A, Kahan T, Gumucio D, Callen DF, Richards RI, Moyzis RK, Doggett NA, Collins FS, Liu PP, Fischel-Ghodsian N, Kastner DL (Jan 1999). "Construction of an ∼700-kb Transcript Map Around the Familial Mediterranean Fever Locus on Human Chromosome 16p13.3". Genome Res. 8 (11): 1172–91. doi:10.1101/gr.8.11.1172. PMC 310791. PMID 9847080.
6. "Entrez Gene: OR2C1 olfactory receptor, family 2, subfamily C, member 1".
7. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• OR2C1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.