OR11H6

Olfactory receptor 11H6 is a protein that in humans is encoded by the OR11H6 gene.[4]

OR11H6
Identifiers
Aliases	OR11H6, olfactory receptor family 11 subfamily H member 6
External IDs	MGI: 3030579 HomoloGene: 27116 GeneCards: OR11H6
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 20,223,710 bp[1] End 20,224,702 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • olfactory receptor activity • signal transducer activity • G-protein coupled receptor activity Cellular component • integral component of membrane • cell membrane • membrane Biological process • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell • signal transduction • response to stimulus • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	122748	258296
Ensembl	ENSG00000176219	ENSMUSG00000050028
UniProt	Q8NGC7	Q7TRL9
RefSeq (mRNA)	NM_001004480	NM_146299
RefSeq (protein)	NP_001004480	NP_666411
Location (UCSC)	Chr 14: 20.22 – 20.22 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]

Ligands

• Isovaleric acid[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000176219 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: OR11H6 olfactory receptor, family 11, subfamily H, member 6".
5. Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D (October 2007). "Genetic elucidation of human hyperosmia to isovaleric acid". PLOS Biology. 5 (11): e284. doi:10.1371/journal.pbio.0050284. PMC 2043052. PMID 17973576.

Further reading

• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR11H6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.