OR8B8

Olfactory receptor 8B8 is a protein that in humans is encoded by the OR8B8 gene.[5][6]

OR8B8
Identifiers
Aliases	OR8B8, TPCR85, olfactory receptor family 8 subfamily B member 8
External IDs	MGI: 2177528 HomoloGene: 56568 GeneCards: OR8B8
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.2 Start 124,437,445 bp[1] End 124,445,696 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A4 Start 37,896,724 bp[2] End 37,903,519 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • odorant binding • olfactory receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • membrane Biological process • sensory perception of smell • signal transduction • response to stimulus • detection of chemical stimulus involved in sensory perception of smell • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26493	258310
Ensembl	ENSG00000197125	ENSMUSG00000066748
UniProt	Q15620	Q60882
RefSeq (mRNA)	NM_012378	NM_146313
RefSeq (protein)	NP_036510	NP_666425
Location (UCSC)	Chr 11: 124.44 – 124.45 Mb	Chr 9: 37.9 – 37.9 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000197125 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066748 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M (Apr 1997). "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species". Genomics. 39 (3): 239–46. doi:10.1006/geno.1996.4490. PMID 9119360.
6. "Entrez Gene: OR8B8 olfactory receptor, family 8, subfamily B, member 8".

Further reading

• Gaudin JC, Breuils L, Haertlé T (2002). "New GPCRs from a human lingual cDNA library". Chem. Senses. 26 (9): 1157–66. doi:10.1093/chemse/26.9.1157. PMID 11705801.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR8B8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.