OR2J2

Olfactory receptor 2J2 is a protein that in humans is encoded by the OR2J2 gene.[3]

OR2J2
Identifiers
Aliases	OR2J2, OR6-19, OR6-8, OR6.3.8, ORL684, dJ80I19.4, hs6M1-6, olfactory receptor family 2 subfamily J member 2
External IDs	HomoloGene: 88922 GeneCards: OR2J2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 29,170,907 bp[1] End 29,175,811 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • membrane Biological process • sensory perception of smell • signal transduction • response to stimulus • detection of chemical stimulus involved in sensory perception of smell • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26707	n/a
Ensembl	ENSG00000226347 ENSG00000225550 ENSG00000226000 ENSG00000196231 ENSG00000204700 ENSG00000232945 ENSG00000231676 ENSG00000234746	n/a
UniProt	O76002	n/a
RefSeq (mRNA)	NM_030905	n/a
RefSeq (protein)	NP_112167	n/a
Location (UCSC)	Chr 6: 29.17 – 29.18 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

Ligands

Agonists include:[4]

• 1-Octanol
• 1-Nonanol
• 1-Decanol
• 1-Heptanol
• Coumarin

See also

• Olfactory receptor

References

1. ENSG00000225550, ENSG00000226000, ENSG00000196231, ENSG00000204700, ENSG00000232945, ENSG00000231676, ENSG00000234746 GRCh38: Ensembl release 89: ENSG00000226347, ENSG00000225550, ENSG00000226000, ENSG00000196231, ENSG00000204700, ENSG00000232945, ENSG00000231676, ENSG00000234746 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: OR2J2 olfactory receptor, family 2, subfamily J, member 2".
4. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Volz A, Ehlers A, Younger R, et al. (2003). "Complex transcription and splicing of odorant receptor genes". J. Biol. Chem. 278 (22): 19691–701. doi:10.1074/jbc.M212424200. PMID 12637542.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• OR2J2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.