OR10H4

Olfactory receptor 10H4 is a protein that in humans is encoded by the OR10H4 gene.[3]

OR10H4
Identifiers
Aliases	OR10H4, OR19-28, olfactory receptor family 10 subfamily H member 4
External IDs	HomoloGene: 113739 GeneCards: OR10H4
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 15,944,299 bp[1] End 15,950,350 bp[1]
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • signal transducer activity • neurotransmitter receptor activity • G-protein coupled serotonin receptor activity • molecular function Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane • dendrite Biological process • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell • signal transduction • response to stimulus • G-protein coupled serotonin receptor signaling pathway • G-protein coupled receptor signaling pathway • biological process • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	126541	n/a
Ensembl	ENSG00000176231	n/a
UniProt	Q8NGA5	n/a
RefSeq (mRNA)	NM_001004465	n/a
RefSeq (protein)	NP_001004465	n/a
Location (UCSC)	Chr 19: 15.94 – 15.95 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000176231 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: OR10H4 olfactory receptor, family 10, subfamily H, member 4".

Further reading

• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (September 2002). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR10H4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.