OR51M1

Olfactory receptor 51M1 is a protein that in humans is encoded by the OR51M1 gene.[5]

OR51M1
Identifiers
Aliases	OR51M1, HOR5'Beta7, OR11-40, olfactory receptor family 51 subfamily M member 1
External IDs	MGI: 3030465 HomoloGene: 64935 GeneCards: OR51M1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 5,383,812 bp[1] End 5,393,263 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 103,928,825 bp[2] End 103,929,784 bp[2]
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • membrane Biological process • sensory perception of smell • signal transduction • response to stimulus • detection of chemical stimulus involved in sensory perception of smell • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	390059	258961
Ensembl	ENSG00000184698	ENSMUSG00000042219
UniProt	Q9H341	F8VPJ9
RefSeq (mRNA)	NM_001004756	NM_001271020 NM_146959
RefSeq (protein)	NP_001004756	NP_001257949
Location (UCSC)	Chr 11: 5.38 – 5.39 Mb	Chr 7: 103.93 – 103.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals.[6] The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000184698 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042219 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR51M1 olfactory receptor, family 51, subfamily M, member 1".
6. Knape K, Beyer A, Stary A, Buchbauer G, Wolschann P (2008). "Genomics of selected human odorant receptors". Chemical Monthly. 139 (12): 1537–1544. doi:10.1007/s00706-008-0957-6.

Further reading

• Bulger M, van Doorninck JH, Saitoh N, et al. (1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 5129–34. doi:10.1073/pnas.96.9.5129. PMC 21828. PMID 10220430.
• Bulger M, Bender MA, van Doorninck JH, et al. (2001). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14560–5. doi:10.1073/pnas.97.26.14560. PMC 18958. PMID 11121057.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR51M1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.