OR1E3

Olfactory receptor family 1 subfamily E member 3 (gene/pseudogene) is a protein that in humans is encoded by the OR1E3 gene. [3]

OR1E3
Identifiers
Aliases	OR1E3, OR17-210, OR1E3P, olfactory receptor family 1 subfamily E member 3 (gene/pseudogene), olfactory receptor family 1 subfamily E member 3
External IDs	GeneCards: OR1E3
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 3,116,427 bp[1] End 3,117,374 bp[1]
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • transmembrane signaling receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • membrane Biological process • G-protein coupled receptor signaling pathway • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell • detection of chemical stimulus involved in sensory perception • signal transduction • response to stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8389	n/a
Ensembl	ENSG00000142163	n/a
UniProt	Q8WZA6 Q9UM77	n/a
RefSeq (mRNA)	NM_001348201	n/a
RefSeq (protein)	NP_001335130	n/a
Location (UCSC)	Chr 17: 3.12 – 3.12 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].

Odorant repertoire

Ketones, in particular acetophenone, act as agonists for OR1E3.[4]

From associations to other olfactory receptors, OR1E3 was found to be associated with the odor tendencies "medicine", "phenol", and "harsh".[5]

References

1. GRCh38: Ensembl release 89: ENSG00000142163 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: Olfactory receptor family 1 subfamily E member 3 (gene/pseudogene)". Retrieved 2020-04-12.
4. Matarazzo V, Clot-Faybesse O, Marcet B, Guiraudie-Capraz G, Atanasova B, Devauchelle G, et al. (March 2005). "Functional characterization of two human olfactory receptors expressed in the baculovirus Sf9 insect cell system". Chemical Senses. 30 (3): 195–207. doi:10.1093/chemse/bji015. PMID 15741602.
5. Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.