OR4F4

Olfactory receptor 4F4 is a protein that in humans is encoded by the OR4F4 gene.[3]

OR4F4
Identifiers
Aliases	OR4F4, OLA-7501, OR4F18, olfactory receptor family 4 subfamily F member 4
External IDs	HomoloGene: 128250 GeneCards: OR4F4
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.3 Start 101,922,042 bp[1] End 101,923,113 bp[1]
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • transmembrane signaling receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • membrane Biological process • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell • detection of chemical stimulus involved in sensory perception • signal transduction • response to stimulus • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26682	n/a
Ensembl	ENSG00000177693 ENSG00000288513	n/a
UniProt	Q96R69	n/a
RefSeq (mRNA)	NM_001004195	n/a
RefSeq (protein)	NP_001004195	n/a
Location (UCSC)	Chr 15: 101.92 – 101.92 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

• Olfactory receptor

References

1. ENSG00000288513 GRCh38: Ensembl release 89: ENSG00000177693, ENSG00000288513 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: OR4F4 olfactory receptor, family 4, subfamily F, member 4".

Further reading

• Trask BJ, Friedman C, Martin-Gallardo A, et al. (1998). "Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes". Hum. Mol. Genet. 7 (1): 13–26. doi:10.1093/hmg/7.1.13. PMID 9384599.
• Mefford HC, Linardopoulou E, Coil D, et al. (2002). "Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes". Hum. Mol. Genet. 10 (21): 2363–72. doi:10.1093/hmg/10.21.2363. PMID 11689483.
• Linardopoulou E, Mefford HC, Nguyen O, et al. (2002). "Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location". Hum. Mol. Genet. 10 (21): 2373–83. doi:10.1093/hmg/10.21.2373. PMID 11689484.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR4F4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.