OR56A4

Olfactory receptor 56A4 is a protein that in humans is encoded by the OR56A4 gene.[4]

OR56A4
Identifiers
Aliases	OR56A4, OR11-49, olfactory receptor family 56 subfamily A member 4
External IDs	MGI: 3030518 HomoloGene: 133596 GeneCards: OR56A4
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 5,999,445 bp[1] End 6,006,946 bp[1]
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • signal transducer activity • adrenergic receptor activity • dopamine neurotransmitter receptor activity, coupled via Gi/Go • dopamine binding Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane • synaptic vesicle membrane Biological process • adenylate cyclase-activating adrenergic receptor signaling pathway • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell • signal transduction • response to stimulus • synaptic transmission, dopaminergic • negative regulation of adenylate cyclase activity • adenylate cyclase-inhibiting dopamine receptor signaling pathway • response to toxic substance • regulation of dopamine secretion • response to drug • regulation of potassium ion transport • behavioral response to cocaine • behavioral response to ethanol • negative regulation of cytosolic calcium ion concentration • negative regulation of synaptic transmission, glutamatergic • phospholipase C-activating dopamine receptor signaling pathway • negative regulation of voltage-gated calcium channel activity • G-protein coupled receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	120793	244187
Ensembl	ENSG00000183389	ENSMUSG00000047225
UniProt	Q8NGH8	Q7TRN8
RefSeq (mRNA)	NM_001005179	NM_207249
RefSeq (protein)	NP_001005179	NP_997132
Location (UCSC)	Chr 11: 6 – 6.01 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]

Ligands

• Decanal[5]
• Undecanal[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000183389 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: OR56A4 olfactory receptor, family 56, subfamily A, member 4".
5. Adipietro KA, Mainland JD, Matsunami H (2012). "Functional evolution of mammalian odorant receptors". PLOS Genetics. 8 (7): e1002821. doi:10.1371/journal.pgen.1002821. PMC 3395614. PMID 22807691.
6. Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC 3990440. PMID 24316890.

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR56A4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.