OR52A1

Olfactory receptor 52A1 is a protein that in humans is encoded by the OR52A1 gene.[5][6]

OR52A1
Identifiers
Aliases	OR52A1, HPFH1OR, olfactory receptor family 52 subfamily A member 1
External IDs	MGI: 1341790 HomoloGene: 130658 GeneCards: OR52A1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 5,143,219 bp[1] End 5,154,757 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 103,774,358 bp[2] End 103,779,698 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • transmembrane signaling receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane Biological process • sensory perception of smell • signal transduction • response to stimulus • detection of chemical stimulus involved in sensory perception of smell • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23538	18369
Ensembl	ENSG00000182070	ENSMUSG00000061626
UniProt	Q9UKL2	E9PYY2
RefSeq (mRNA)	NM_012375	NM_013620
RefSeq (protein)	NP_036507	NP_038648
Location (UCSC)	Chr 11: 5.14 – 5.15 Mb	Chr 7: 103.77 – 103.78 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000182070 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061626 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Feingold EA, Penny LA, Nienhuis AW, Forget BG (Nov 1999). "An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells". Genomics. 61 (1): 15–23. doi:10.1006/geno.1999.5935. PMID 10512676.
6. "Entrez Gene: OR52A1 olfactory receptor, family 52, subfamily A, member 1".

Further reading

• Bulger M, Bender MA, van Doorninck JH, et al. (2001). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14560–5. doi:10.1073/pnas.97.26.14560. PMC 18958. PMID 11121057.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• OR52A1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.