OR2M7

Olfactory receptor 2M7 is a protein that in humans is encoded by the OR2M7 gene.[3]

OR2M7
Identifiers
Aliases	OR2M7, OR1-58, olfactory receptor family 2 subfamily M member 7
External IDs	OMIM: 618509 HomoloGene: 133839 GeneCards: OR2M7
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q44 Start 248,323,630 bp[1] End 248,324,568 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • olfactory receptor activity • G-protein coupled receptor activity Cellular component • cell membrane • membrane • integral component of membrane Biological process • sensory perception of smell • signal transduction • response to stimulus • detection of chemical stimulus involved in sensory perception of smell • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	391196	n/a
Ensembl	ENSG00000177186	n/a
UniProt	Q8NG81	n/a
RefSeq (mRNA)	NM_001004691	n/a
RefSeq (protein)	NP_001004691	n/a
Location (UCSC)	Chr 1: 248.32 – 248.32 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

Ligands

Agonists include:[4]

• (-)-Citronellol
• Geraniol

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000177186 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: OR2M7 olfactory receptor, family 2, subfamily M, member 7".
4. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

External links

• OR2M7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.