OR5T1

Olfactory receptor 5T1 is a protein that in humans is encoded by the OR5T1 gene.[3]

OR5T1
Identifiers
Aliases	OR5T1, OR11-179, OR5T1P, olfactory receptor family 5 subfamily T member 1
External IDs	HomoloGene: 133608 GeneCards: OR5T1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 56,274,154 bp[1] End 56,276,819 bp[1]
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • signal transducer activity • adrenergic receptor activity • dopamine neurotransmitter receptor activity, coupled via Gi/Go • dopamine binding Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane • synaptic vesicle membrane • intracellular Biological process • adenylate cyclase-activating adrenergic receptor signaling pathway • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell • signal transduction • response to stimulus • synaptic transmission, dopaminergic • negative regulation of adenylate cyclase activity • adenylate cyclase-inhibiting dopamine receptor signaling pathway • response to toxic substance • regulation of dopamine secretion • response to drug • regulation of potassium ion transport • behavioral response to cocaine • behavioral response to ethanol • negative regulation of cytosolic calcium ion concentration • negative regulation of synaptic transmission, glutamatergic • phospholipase C-activating dopamine receptor signaling pathway • negative regulation of voltage-gated calcium channel activity • G-protein coupled receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	390155	n/a
Ensembl	ENSG00000181698 ENSG00000262784	n/a
UniProt	Q8NG75	n/a
RefSeq (mRNA)	NM_001004745	n/a
RefSeq (protein)	NP_001004745	n/a
Location (UCSC)	Chr 11: 56.27 – 56.28 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

• Olfactory receptor

References

1. ENSG00000262784 GRCh38: Ensembl release 89: ENSG00000181698, ENSG00000262784 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: OR5T1 olfactory receptor, family 5, subfamily T, member 1".

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR5T1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.